Fast Mars communication geometry program

Computer program calculates trajectories of orbiting spacecraft and lander vehicles simultaneously. Using data from both vehicles, program calculates communications geometry which consists of orbiting spacecraft cone/clock angle, lander cone/clock angle, range, range rate and acceleration, and fade, reflective, and system margins

Overgeneral past and future thinking in dysphoria: the role of emotional cues and cueing methodology

Overgeneral memory, where individuals exhibit difficulties in retrieving specific episodes from autobiographical memory, has been consistently linked with emotional disorders. However, the majority of this literature has relied upon a single methodology, in which participants respond to emotional cue words with explicit instructions to retrieve/simulate specific events. Through use of sentence completion tasks the current studies explored whether overgenerality represents a habitual pattern of thinking that extends to how individuals naturally consider their personal past and future life story. In both studies, when compared with controls, dysphoric individuals evidenced overgeneral thinking style with respect to their personal past. However, overgeneral future thinking was only evident when the sentence stems included emotional words. These findings highlight the importance of investigating the overgenerality phenomenon using a variety of cueing techniques and results are discussed with reference to the previous literature exploring overgenerality and cognitive models of depression

Conductivity in Jurkat cell suspension after ultrashort electric pulsing

Ultrashort electric pulses applied to similar cell lines such as Jurkat and HL-60 cells can produce markedly different results , which have been documented extensively over the last few years. We now report changes in electrical conductivity of Jurkat cells subjected to traditional electroporation pulses (50 ms pulse length) and ultrashort pulses (10 ns pulse length) using time domain dielectric spectroscopy (TDS). A single 10 ns, 150 kV/cm pulse did not noticeably alter suspension conductivity while a 50 ms, 2.12 kV/cm pulse with the same energy caused an appreciable conductivity rise. These results support the hypothesis that electroporation pulses primarily interact with the cell membrane and cause conductivity rises due to ion transport from the cell to the external media, while pulses with nanosecond duration primarily interact with the membranes of intracellular organelles. However, multiple ultrashort pulses have a cumulative effect on the plasma membrane, with five pulses causing a gradual rise in conductivity up to ten minutes post-pulsing

A Preliminary Evaluation of Mounds to Divert Wayward Vehicles Away from Rigid Obstructions

In the summer of 1965, the first fatality report involving an interstate median bridge pier in Kentucky caused concern among state and national officials for the safety of motorists who perchance or otherwise enter upon a collision course toward an unprotected bridge pier. A consensus of opinion seemed to indicate that some form of attenuation or deflection device was necessary. Early innovations employed various short guardrail configurations to deflect wayward vehicles from the piers. The use of small, short sections has since evolved until present methods include surrounding the bridge pier with several hundred feet of guardrail, including ramped-end treatment (see Figure 1). The use of guardrail has not been questioned from the standpoint of safety design, yet some effort has been applied by Kentucky and other states to finding an alternative approach. From these efforts, the use of mounds to decelerate and deflect vehicles originated. It was thought that this design concept was consistent with current safety developments as well as being an economical treatment of the problem, since most of the work involved in constructing the mound can be done during grade and drain construction using natural materials available on location. These mounds have since been constructed on certain interstate projects and on all bridge locations of the Jackson Purchase (51.4 miles) and Pennyrile (56.6 miles) Parkways in Kentucky. Having found no records of accidents involving these mounds in the interim, there has been no substantial means of evaluating the effectiveness of this innovation in preventing or reducing the severity of collisions with bridge piers. Consequently, it was decided that low speed excursions over a mound might provide a basis for evaluation. The Division of Research made a series of driver-controlled traverses at low speeds on a typical site constructed on a 60-foot median. The purpose of this report is to summarize the results obtained from these initial, low-speed tests and, in so doing, attempt to make some determination of the reliability of this particular type of earthwork. It is anticipated that these low-speed tests will be supplemented eventually by testing at higher speeds, using some form of remote guidance system in place of the human driver. Also, it must be emphasized that conclusions drawn from this report apply only to low-speed encroachments. Additional effects which may be encountered during high-speed testing can only be hypothesized at this time

Increased plasticity of the bodily self in eating disorders

Background: The rubber hand illusion (RHI) has been widely used to investigate the bodily self in healthy individuals. The aim of the present study was to extend the use of the RHI to examine the bodily self in eating disorders. Methods: The RHI and self-report measures of eating disorder psychopathology (EDI-3 subscales of Drive for Thinness, Bulimia, Body Dissatisfaction, Interoceptive Deficits, and Emotional Dysregulation; DASS-21; and the Self-Objectification Questionnaire) were administered to 78 individuals with an eating disorder and 61 healthy controls. Results: Individuals with an eating disorder experienced the RHI significantly more strongly than healthy controls on both perceptual (i.e., proprioceptive drift) and subjective (self-report questionnaire) measures. Furthermore, both the subjective experience of the RHI and associated proprioceptive biases were correlated with eating disorder psychopathology. Approximately 20% of the variance for embodiment of the fake hand was accounted for by eating disorder psychopathology, with interoceptive deficits and self-objectification significant predictors of embodiment. Conclusions: These results indicate that the bodily self is more plastic in people with an eating disorder. These findings may shed light on both aetiological and maintenance factors involved in eating disorders, particularly visual processing of the body, interoceptive deficits, and self-objectification

Surveying structural complexity in quantum many-body systems

Quantum many-body systems exhibit a rich and diverse range of exotic behaviours, owing to their underlying non-classical structure. These systems present a deep structure beyond those that can be captured by measures of correlation and entanglement alone. Using tools from complexity science, we characterise such structure. We investigate the structural complexities that can be found within the patterns that manifest from the observational data of these systems. In particular, using two prototypical quantum many-body systems as test cases - the one-dimensional quantum Ising and Bose-Hubbard models - we explore how different information-theoretic measures of complexity are able to identify different features of such patterns. This work furthers the understanding of fully-quantum notions of structure and complexity in quantum systems and dynamics.Comment: 9 pages, 5 figure

SARS: Systematic review of treatment effects

Background The SARS outbreak of 2002-2003 presented clinicians with a new, life-threatening disease for which they had no experience in treating and no research on the effectiveness of treatment options. The World Health Organization ( WHO) expert panel on SARS treatment requested a systematic review and comprehensive summary of treatments used for SARS-infected patients in order to guide future treatment and identify priorities for research. Methods and Findings In response to the WHO request we conducted a systematic review of the published literature on ribavirin, corticosteroids, lopinavir and ritonavir (LPV/r), type I interferon (IFN), intravenous immunoglobulin ( IVIG), and SARS convalescent plasma from both in vitro studies and in SARS patients. We also searched for clinical trial evidence of treatment for acute respiratory distress syndrome. Sources of data were the literature databases MEDLINE, EMBASE, BIOSIS, and the Cochrane Central Register of Controlled Trials ( CENTRAL) up to February 2005. Data from publications were extracted and evidence within studies was classified using predefined criteria. In total, 54 SARS treatment studies, 15 in vitro studies, and three acute respiratory distress syndrome studies met our inclusion criteria. Within in vitro studies, ribavirin, lopinavir, and type I IFN showed inhibition of SARS-CoV in tissue culture. In SARS-infected patient reports on ribavirin, 26 studies were classified as inconclusive, and four showed possible harm. Seven studies of convalescent plasma or IVIG, three of IFN type I, and two of LPV/r were inconclusive. In 29 studies of steroid use, 25 were inconclusive and four were classified as causing possible harm. Conclusions Despite an extensive literature reporting on SARS treatments, it was not possible to determine whether treatments benefited patients during the SARS outbreak. Some may have been harmful. Clinical trials should be designed to validate a standard protocol for dosage and timing, and to accrue data in real time during future outbreaks to monitor specific adverse effects and help inform treatment

Nanosecond electric pulses penetrate the nucleus and enhance speckle formation

Nanosecond electric pulses generate nanopores in the interior membranes of cells and modulate cellular functions. Here, we used confocal microscopy and flow cytometry to observe Smith antigen antibody (Y12) binding to nuclear speckles, known as small nuclear ribonucleoprotein particles (snRNPs) or intrachromatin granule clusters (IGCs), in Jurkat cells following one or five 10 ns, 150 kV/cm pulses. Using confocal microscopy and flow cytometry, we observed changes in nuclear speckle labeling that suggested a disruption of pre-messenger RNA splicing mechanisms. Pulse exposure increased the nuclear speckled substructures by 2.5-fold above basal levels while the propidium iodide (PI) uptake in pulsed cells was unchanged. The resulting nuclear speckle changes were also cell cycle dependent. These findings suggest that 10 ns pulses directly influenced nuclear processes, such as the changes in the nuclear RNA–protein complexes